August 14, 2022

Scientists Establish Protein That Can Reverse Muscle Loss Ageing

There is no such thing as a magic tablet to reversing getting old and going again to your youth immediately.

With that mentioned, science has now found {that a} protein referred to as NANOG, could result in one thing as near reversing age-related skeletal muscle loss.

Right here is the inside track.

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Protein to Reverse Muscle Loss Ageing

The analysis might assist result in remedies for atherosclerosis, osteoporosis and different age-related issues (Credit score: College of Buffalo)

Researchers on the College at Buffalo, NY have discovered that over-expression of NANOG, a protein will help reverse muscle acquire.

A protein with the identify of the fabled land of youth in Irish legend has been confirmed to efficiently cease the getting old of skeletal muscle cells by a analysis group led by the College at Buffalo.

The NANOG protein, which has its origins in Tír na nÓg, a location in Irish folklore related to youth, magnificence, and well being, is the topic of the research, which was revealed in Science Advances.

The embryonic progenitors of muscle tissue often known as myoblasts had been overexpressed with NANOG by the researchers in a collection of checks. Myoblasts that had reached senescence had been not able to proliferating or dividing.

The main traits of aging-related mobile depletion, corresponding to autophagy, vitality stability, genomic stability, nuclear integrity, and mitochondrial perform, had been all enhanced by overexpression.


NANOG, specifically, boosted the amount of muscle stem cells within the muscle groups of mice that had been prematurely getting old. This confirmed that mobile getting old could possibly be reversed within the physique with out the necessity to reprogram cells into an embryonic pluripotent state, which is a typical process in stem cell remedy however has the potential to trigger most cancers.

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